Week 9 DB Pharm
Group 3: WG has made it through withdrawal without complications thanks to an appropriate management regimen. She would like to consider pharmacological treatment to maintain abstinence. Her LFTs have normalized now that she has been alcohol-free for the past week. She reports taking disulfiram during previous rehabilitation attempts but was unsuccessful, most likely because of adherence issues. Her medical chart indicates she has great insurance so prescription copayments shouldn’t be a problem.
What abstinence medication would be most appropriate for WG?
Post your initial response by Wednesday at midnight. Respond to at least one student with a different assigned DB question by Sunday at midnight. Both responses must be a minimum of 150 words, scholarly written, APA formatted, and referenced. A minimum of 2 references are required (other than your text). Refer to the Grading Rubric for Online Discussion in the Course Resource section.
Week 9 DB Pharm
WG in our case is said to have made it through a withdrawal safely following the appropriate management regimen. Buddy, (2021) reveals that withdrawal is a combination of mental and physical effects that an individual experience after declining or reducing the intake of substances like alcohol and prescription or recreational drugs. That’s the case with our patient following alcohol addiction. According to Galbicsek (2021), alcohol withdrawal is a change a body undergoes after an individual abruptly stops drinking following an extended and heavy use of alcohol. Over time, both the body and brain become dependent on drinking incidence and patterns. When individuals abruptly stop taking alcohol, their bodies are deprived of alcohol effects and require time for change to function without it. This particular adjustment period causes painful side effects of alcohol withdrawal like insomnia, shakes, anxiety, and nausea.
WG reported taking disulfiram on her previous rehabilitation attempts, although it was unsuccessful, most probably following adherence issues. Despite approval by the U.S. Food and Drug Administration, Disulfiram, as an aversive agent and having been in use for over forty years, has notable adverse effects and difficulties in compliance. It has no clear evidence in increasing abstinence rates, decreasing rates of relapse, or reducing cravings. Therefore, the most appropriate abstinence medication that can be recommended for WG is Naltrexone. This medication is an opioid receptor antagonist approved by U.S. Food and Drug Administration for use in managing alcohol dependence (Palpacuer et al., 2018). Naltrexone is believed to work through its obstruction of the opioid receptors that reduce reinforcing effects of alcohol, leading to reduced feelings of intoxication and fewer cravings.
Buddy T. (2021). What is drug withdrawal? Verywell Mind. https://www.verywellmind.com/what-is-withdrawal-how-long-does-it-last-63036#
Galbicsek. (2021, June 22). Alcohol Withdrawal. Alcohol Rehab Guide. https://www.alcoholrehabguide.org/alcohol/withdrawal/
Palpacuer, C., Duprez, R., Huneau, A., Locher, C., Boussageon, R., Laviolle, B., & Naudet, F. (2018). Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta‐analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate. Addiction, 113(2), 220-237. https://doi.org/10.1111/add.13974