VET10080 Cell and Whole Body Metabolism
Academic Year 2021/2022
This module focuses on the pathways of intermediary metabolism, with particular reference to domestic animals. It describes the main pathways of intermediary metabolism, their relationship to each other, and how they are regulated by hormones. Students learn about macromolecules such as proteins, enzyme activity and regulation, and the main pathways of carbohydrate, amino acid, and lipid metabolism. These pathways are illustrated using examples from various domestic species. This module describes how precursors generated in these pathways are used to generate compounds such as nucleic acids, hormones, and neurotransmitters. The hormonal regulation of metabolic pathways in different species is discussed, with reference to clinical veterinary scenarios. The metabolic function of vitamins and minerals and their relevance to health and disease is discussed in the context of ruminant and monogastric species.
On completion of this module students should be able to:
1. Describe the essential elements of cell metabolism, including structures of proteins, carbohydrates and lipids, enzyme kinetics, and how enzyme activity is regulated.
2. Describe the central pathways of carbohydrate, lipid, amino acid and protein metabolism in domestic animals
3. Display an understanding of the processes by which cells obtain energy (glycolysis, TCA cycle, mitochondrial oxidative phosphorylation)
4. Display an understanding of metabolic processes within cells, understand the role of hormones (e.g. insulin and glucagon) in regulating metabolism in different domestic species, and be able to describe some of the clinical implications of deficiencies in these hormones.
5. Understand how vitamins and minerals are required for many cellular functions, and some of the pathological effects of deficiency or oversupply of these in domestic animals.
6. Be aware of current research themes in this area.
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