PATH40080 High Throughput Technologies
Academic Year 2021/2022
Rapid technological advances have made high-throughput technologies available for the study of biological systems, laying the foundation for the development of the “-omics” era. This offers the ability to carry out high-throughput studies characterized by big data production. Indeed, the completion of the first human genome sequence and the availability of high-scale technological tools have made it possible to study genomics, transcriptomics, epigenomics, and other -omic sciences at a previously unthinkable level. The integration of these disciplines is further increasing our understanding of the molecular bases of human diseases. This module aims to offer a comprehensive overview of the fundamentals of omic sciences and the potential of the datasets emerging from these technologies to diagnose, monitor, and target many common diseases.
On completion of this module students should be able to:
1) Explain fundamental principles of genome, epigenome, transcriptome, proteome and metabolome biology.
2) Describe the various high-throughput technologies available to investigate biological systems in health and disease.
3) Outline the advantages/limitations of different omics approaches, and key factors underlying choice of biological material for studies.
Indicative Module Content:
This module aims to offer a comprehensive overview of the fundamentals of omics sciences and the potential of the datasets emerging from these technologies to diagnose, monitor, and target many common diseases. Topics covered include introductory lectures to explore fundamental principles of the human genome, transcriptome, epigenome, proteome and metabolome. Applications/Technology lectures will cover practical consideration in biological sample sourcing, best practices, sample preparation, technological solutions and interpretation. Content will be delivered by UCD School of Medicine staff as well as invited expert lecturers with pharma experience.
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