PATH40060 Precision Oncology
Academic Year 2021/2022
The Precision Oncology module outlines i) the scientific basis for precision oncology research, and ii) precision oncology tools (e.g., diagnostic molecular tests) available in routine clinical settings and in development. We will discuss the current genomics and other -omics technologies used for precision oncology; and how the genetic, genomic and molecular information generated aid the screening, diagnosis, classification, treatment selection, risk stratification, treatment response, and monitoring of cancer.
Seminars/Webinars are grouped around the major topics of molecular basis of tumorigenesis, cancer genomics, molecular oncology and network biology which will be accompanied by tutorials. The course is delivered by scientists, bioinformaticians, pathologists, and clinicians, reflecting on the multidisciplinary approach to personalized patient care. Students will also have opportunity to observe multidisciplinary team meetings (MDT) and molecular MDTs which are crucial to the successful translation of the molecular data into true benefit for patients.
Assessment is based on group projects, presentations, and portfolio throughout the year.
Following the completion of this module you will be expected to:
1. Understand how precision oncology helps doctors to select the right targeted treatment in the right dose at the right time for each patient based on the genetic and molecular understanding of their individual disease.
2. Develop a multidisciplinary mindset to understand precision oncology research, and to be able to translate it into the clinic.
3. Understand the basic concepts of the technologies/platforms (e.g., genomics, proteomics etc.) used in precision oncology.
4. Be able to interpret the genetic, genomic, and other molecular data generated; and recognize actionable targets, predictive and prognostic markers.
5. Identify the main molecular diagnostic tests currently used in clinical practice; and be aware of molecular tests coming down the line.
6. Understand the importance of multidisciplinary approaches in patient care; understand the diagnostic work-up of a cancer patient, the role of the pathologist and bioinformatician in making a precise diagnosis; the impact of this diagnosis on the subsequent treatment of the patient.
Indicative Module Content: