Mechanism of Action for Biologic Drug

Mechanism of Action for Biologic Drug

Mechanism of Action for Biologic Drug 150 150 Peter

Mechanism of Action for Biologic Drug

Explain the mechanism of action of a ‘biologic drug’
Identify two advantages and two disadvantages of using this medication for chronic disease states
Provide a patient case and drug treatment plan to support it

Sample Paper

Advanced Pharmacology

According to Marks (2021), biologic drugs are human-made proteins intended to zero in on immune system parts that usually cause inflammation. These drugs come from the living source, either animal or human. Some examples of biologics include hormones, cytokines, blood products, growth factors, gene, cellular therapies, vaccines, fusion proteins, interferon, insulin, and monoclonal antibody products.

Mechanism of Action for Biologic Drug

Biologics hinder the main inflammatory molecules thought to be elaborate in the pathogenesis of these particular chronic inflammatory conditions and physiologic immune responses (Cronstein & Aune, 2020).

Advantages and Disadvantages of Biologic Medication for Chronic Disease

Generally, biologics may treat various chronic disorders, like Psoriasis, cancer, rheumatoid arthritis, and inflammatory bowel illnesses such as Crohn’s illness. One advantage of biologic medications in chronic conditions is their effectiveness in controlling the symptoms and avoiding complications. Another significant advantage in these conditions is the medications fast action onset and high response rate.

One disadvantage is that biologic medications may cause many potentially severe side effects. As these drugs affect the immune system, they increase an individual’s infection risk, counting tuberculosis. As well, some of biologic drugs have been associated with the development of lymphoma, which is a cancer of white blood cells (Klein, Polliack & Gafter‐Gvili, 2018).

Patient Case and Drug Treatment Plan

A.A, a 51-year-old Caucasian male, presented in the facility accompanied by his son. He complained of red patches in the skin, dry, cracked skin that bled, and swollen and stiff joints for the previous three weeks. Upon completing an assessment via skin biopsy, it was defined that the patient had Psoriasis. Psoriasis is a common chronic illness with no cure. It tends to go through the cycles, flaring for a few weeks or months and then subsiding for a while or going to remission.

For the drug treatment plan, A.A can be recommended Abatacept as an appropriate biologic drug. This drug would target the cause of the inflammation-reducing activity of the immune system. The patient can be advised to get it in a prefilled pen or an auto-injector giving a shot once every week for roughly 3-4 months.

 

References

Cronstein, B. N., & Aune, T. M. (2020). Methotrexate and its mechanisms of action in inflammatory arthritis. Nature Reviews Rheumatology16(3), 145-154. https://doi.org/10.1038/s41584-020-0373-9

Klein, A., Polliack, A., & Gafter‐Gvili, A. (2018). Rheumatoid arthritis and lymphoma: Incidence, pathogenesis, biology, and outcome. Hematological Oncology36(5), 733-739. https://doi.org/10.1002/hon.2525

Marks, J. (2021, June 29). Biologic medications and side effects. WebMD. https://www.webmd.com/drug-medication/biologic-medications-and-side-effects